This is the original Neverwinter Nights (NWN) 1 module where you should start off with a male character (though you can pick female if you wish). The plot revolves around M2F however though the game is still playable either way, you just can't do the M2F questline. Basically explore a relatively huge game world including a mysterious mansion in the woods, a little town outside the mansion and a large sprawling series of zones (areas) of the game world as you level up and complete various quests. Available at the NWN Vault site here with instructions on how to set it up (requires an older CEP expansion pack than the current version): http://nwvault.ign.com/View.php?view=modules.Detail&id=4356 

Takes place decades after a great wizard war. You must break a curse on the Witch Queen by defeating the wizard Funder before he starts another war. This game contains transformation magic including male to female sex change, were-rat, and chicken.

Mactery Bob, Draxxar, Warmag, Notten, to name a few.